What is the 7-Dehydrocholesterol?

7-Dehydrocholesterol is white to off-white fine crystalline powder, while it's Molecular Formula is C27H44O. white to off-white fine crystalline powder A vitamin D3 precursor.

What is the CAS number for 7-Dehydrocholesterol?

The CAS number of 7-Dehydrocholesterol is 434-16-2.

What is 7-Dehydrocholesterol (434-16-2) used for?

7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 . 7-DHC is a provitamin that is converted to vitamin D3 by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.InChI:InChI=1/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1

What is the 7-Dehydrocholesterol?

7-Dehydrocholesterol is white to off-white fine crystalline powder, while it's Molecular Formula is C27H44O. white to off-white fine crystalline powder A vitamin D3 precursor.

What is the CAS number for 7-Dehydrocholesterol?

The CAS number of 7-Dehydrocholesterol is 434-16-2.

What is 7-Dehydrocholesterol (434-16-2) used for?

7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 . 7-DHC is a provitamin that is converted to vitamin D3 by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.InChI:InChI=1/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1

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434-16-2

Product Name：Intermediate
Molecular Formula：C₂₇H₄₄O
Purity：99%
Molecular Weight：384.646

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Product Details

Quality Manufacturer Supply High Purity 99% Intermediate 434-16-2 with Reasonable Price

Molecular Formula:C27H44O
Molecular Weight:384.646
Appearance/Colour:white to off-white fine crystalline powder
Vapor Pressure:8.08E-12mmHg at 25°C
Melting Point:148-152 °C(lit.)
Refractive Index:1.535
Boiling Point:493.744 °C at 760 mmHg
PKA:14.91±0.70(Predicted)
Flash Point:212.294 °C
PSA：20.23000
Density:1.002 g/cm³
LogP:7.30880

7-Dehydrocholesterol(Cas 434-16-2) Usage

Biochem/physiol Actions	Down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.
General Description	7-Dehydrocholesterol (7-DHC), a 5,7-conjugated diene sterol is a biosynthetic precursor of cholesterol. It helps in the production of vitamin D3 when exposed to ultraviolet B (UVB) radiation.

InChI:InChI=1/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1

434-16-2 Relevant articles

Oxidation of cholesterol by a biomimetic oxidant, cetyltrimethylammonium dichromate

Patel, Sabita,Mishra

, p. 3522 - 3526 (2006)

The oxidation of cholesterol by cetyltri...

Novel industrial method for preparing vitamin D3 by taking stigmasterol as raw material

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Paragraph 0010; 0052; 0053, (2021/05/05)

The invention provides a novel industria...

PREPARATION OF 7-DEHYDROCHOLESTEROL USING SPECIFIC AROMATIC SOLVENTS

-

Page/Page column 16, (2021/10/30)

The present invention relates to a new s...

ORGANIC SOLVENT NANOFILTRATION OF 7-DEHYDROCHOLESTEROL OR 25-HYDROXY-7-DEHYDROCHOLESTEROL OR THEIR OH PROTECTED FORMS

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Page/Page column 20, (2021/10/30)

The present invention relates to the pur...

IMPROVED, COST EFFECTIVE PROCESS FOR SYNTHESIS OF VITAMIN D3 AND ITS ANALOGUE CALCIFEDIOL FROM ERGOSTEROL

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Page/Page column 23; 43, (2021/01/29)

Disclosed herein is an improved and effi...

434-16-2 Process route

: 1059-86-5
7-Dehydrocholesteryl acetate

: 434-16-2
7-dehydrocholesterol

Conditions

Conditions	Yield
With alkali metal hydroxide; In methanol; at 50 ℃; Large scale;	91%
With methanol; at 50 ℃; Large scale;	90%
With sodium hydroxide; In ethanol; at 80 ℃; for 0.5h;	85.4%
With sodium tetrahydroborate; In methanol;
With water; sodium hydroxide; In methanol; at 28 - 70 ℃; Temperature;
With potassium hydroxide;
With water; potassium hydroxide;