456-22-4
- Product Name：4-Fluorobenzoic acid
- Molecular Formula：C7H5FO2
- Purity：99%
- Molecular Weight：140.114
Product Details
Reliable Quality 4-Fluorobenzoic acid 456-22-4 Hot Sale with Chinese Manufacturer
- Molecular Formula:C7H5FO2
- Molecular Weight:140.114
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:0.00936mmHg at 25°C
- Melting Point:184 °C
- Refractive Index:1.537
- Boiling Point:253.7 °C at 760 mmHg
- PKA:4.15(at 25℃)
- Flash Point:107.2 °C
- PSA：37.30000
- Density:1.319 g/cm3
- LogP:1.52390
4-Fluorobenzoic acid(Cas 456-22-4) Usage
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Reference |
AG. Vaidyanathan, M. R. Zalutsky, Improved Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate and Its Application to the Labeling of a Monoclonal Antibody Fragment, Bioconjuate Chemistry, 1994, vol. 5, pp. 352-356 |
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Purification Methods |
Crystallise the acid from 50% aqueous EtOH, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333, 9 III 1327, 9 IV 953.] |
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Definition |
ChEBI: A fluorobenzoic acid carrying a fluoro substituent at position 4. |
InChI:InChI=1/C7H5FO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)
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456-22-4 Process route
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2729-19-3
2-(4-Fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one
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456-22-4
4-Fluorobenzoic acid
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100-09-4
4-methoxybenzoic acid
| Conditions | Yield |
|---|---|
|
With
oxygen; potassium hydroxide;
at 20 ℃;
chemoselective reaction;
Schlenk technique;
|
96% 95% |
-
-
2729-18-2
1-(4-fluorophenyl)-2-(4-methoxyphenyl)ethan-1-one
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-
456-22-4
4-Fluorobenzoic acid
-
-
100-09-4
4-methoxybenzoic acid
| Conditions | Yield |
|---|---|
|
With
oxygen; potassium hydroxide;
at 20 ℃;
chemoselective reaction;
Schlenk technique;
|
96% 94% |
456-22-4 Upstream products
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595-07-3
1,2-bis-(4-fluoro-phenyl)-1,2-diphenyl-ethane-1,2-diol
-
75-36-5
acetyl chloride
-
94-09-7
p-aminoethylbenzoate
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65972-02-3
N-Trimethylammonio-p-fluorbenzamidat
456-22-4 Downstream products
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451-46-7
4-fluorobenzoic acid ethyl ester
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459-56-3
4-fluorobenzylic alcohol
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403-33-8
methyl 4-flurobenzoate
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453-71-4
3-nitro-4-fluorobenzoic acid
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