546-88-3

Manufacturing Process

3 Methods of producing of acetohydroxamic acid: 1. Ethyl acetic acid ether was treated with hydroxylamine and acetohydroxamic acid was obtained. 2. Acetohydroxamic acid was obtained in the result of reaction of acetamide with hydroxylamine. 3. Acetohydroxamic acid was obtained by treatment of acetaldehyde with nitrohydroxylamine.

Therapeutic Function

Urease inhibitor

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Call your doctor at once if you have:pounding heartbeats or fluttering in your chest;signs of a blood clot in your leg --pain, swelling, warmth, or redness in one or both legs;signs of a red blood cell disorder --pale or yellowed skin, dark colored urine, fever, confusion or weakness.Common side effects may include:headache during the first 2 days of treatment;skin rash, warmth, tingling or redness (especially if you drink alcohol while taking acetohydroxamic acid);upset stomach, nausea, loss of appetite;depressed mood;anxiety, tremors, nervousness;hair loss.

Safety Profile

Moderately toxic by intraperitonealroute. An experimental teratogen. Other experimentalreproductive effects. Mutation data reported. When heatedto decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Acetohydroxamic acid can be used in dogs as adjunctive therapy in some cases of recurrent urolithiasis or in the treatment of persistent urinary tract infections caused by the following bacteria: E. coli, Klebsiella, Morganella morganii, Staphylococci spp., and Pseudomonas aeruginosa. Adverse effects limit its usefulness.

Brand name

Lithostat (Mission).

General Description

Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.